HerpesFolds

This table gives interactive access to the complete predicted structures of all 9 human herpesvirus proteomes. For simplicity, we have excluded ColabFold predictions of two more animal model herpesviruses (PRV and MHV-68). You can find the full list here.

For help evaluating the predictions, please check this quick tutorial.

NEW: We have used Foldseek to cluster all human herpesvirus protein predictions into structural similarity clusters. You can find the interactive clusters here!

The table aims to group structurally similar proteins and homologs between viruses into one line. Please contact us if you find any that we did not group.

Please use the search field on the right for super-fast access to the database.

Methods: All proteins were run in ColabFold first for speed. We then used three thresholds based on pLDDT and pTM to quality-control our predictions (see the MM’s for details). If a model failed any threshold, we rerun that protein using standard AlphaFold 2.3. On the respective model pages, you will find the AlphaFold predictions first. We note on the top of each corresponding page, if both ColabFold and AlphaFold predictions failed the thresholds. Check out the materials and methods if you are interested in the details.

Structure GroupProteinDescriptionHSV-1HSV-2VZVHCMVHHV-6AHHV-6BHHV-7EBVKSHV
alkaline nucleaseANAlkaline nuclease
UL12
P04294
UL12
P89435
ORF48
P09253
UL98
F5HF49
U70
P24447
U70
P52448
U70
Q77Y54
BGLF5
P03217
ORF37
Q2HR95
alkaline nucleaseANAlkaline nuclease (isoform 12.5)
UL12_UL12.5
P04294
ARBHApoptosis regulator Bcl-2 homolog (vBcl-2)
ORF16
F5HGJ3
B1Protein B1
B1
Q9PX69
B2Protein B2
B2
Q9PX71
B3Protein B3
B3
Q9PX43
B4Protein B4
B4
Q9QJ59
B5Protein B5
B5
Q9QJ58
B6Protein B6
B6
Q96895
B7Protein B7
B7
Q69066
B8Protein B8
B8
Q9QJ13
B9Protein B9
B9
Q9QJ10
CCU83Putative CC-type chemokine U83
U83
P52460
U83
P52461
viral CXCL1CEP1Cytoplasmic envelopment protein 1
UL7
P10191
UL7
P89430
ORF53
P09301
UL103
F5HA10
U75
P52456
U75
P52457
U75
Q77Y50
BBRF2
P29882
ORF42
F5HAI6
cytoplasmic envelopment protein 2CEP2Cytoplasmic envelopment protein 2
UL16
P10200
UL16
P89439
ORF44
P09293
UL94
F5HAC7
U65
P24442
U65
Q9QJ19
U65
O56292
BGLF2
P0CK53
ORF33
F5HEF2
CEP3Cytoplasmic envelopment protein 3
UL11
P04289
UL11
P13294
ORF49
P09297
UL99
F5HI87
U71
P24448
U71
P52459
U71
Q77Y53
BBLF1
P0CK51
ORF38
F5HHY1
capsid vertex component 1CVC1Capsid vertex component 1
UL17
P10201
UL17
P89440
ORF43
P09292
UL93
Q6SW50
U64
P24441
U64
Q9QJ20
U64
O56291
BGLF1
P03222
ORF32
F5HB39
capsid vertex component 2CVC2Capsid vertex component 2
UL25
P10209
UL25
P89448
ORF34
P09287
UL77
Q6SW65
U50
P52387
U50
P52537
U50
O56285
BVRF1
P03233
ORF19
Q2HRB3
CXCL1Chemokine vCXCL1
UL146
F5HBX1
major DNA-binding proteinDBPMajor DNA-binding protein
UL29
P04296
UL29
P89452
ORF29
P09246
UL57
F5HDQ6
U41
P52338
U41
P52538
U41
O56282
BALF2
P03227
ORF6
Q2HRD3
DNA polymerase and helicase/primaseDPOLDNA polymerase
UL30
P04293
UL30
P89453
ORF28
P09252
UL54
Q6SW77
U38
P28857
U38
Q9QJ32
U38
O92827
BALF5
P03198
ORF9
Q2HRD0
US22_2DR1Uncharacterized protein DR1
DR1
Q89746
DR1
Q9PWX1
DR1
O57297
DR3Uncharacterized protein DR3
DR3
Q9PX32
US22_2DR6Uncharacterized protein DR6
DR6
Q89584
DR6
Q9PX53
DR6
O57302
DUT_2DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase)
UL50
P10234
UL50
P89469
ORF8
P09254
UL72
Q6SW70
U45
Q06095
U45
P52541
U45
Q77Y69
BLLF3
P03195
ORF54
Q2HR78
dihydrofolate reductaseDYRPutative Dihydrofolate reductase
ORF2
Q2HRC6
EARApoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)
BHRF1
P03182
snake C-type lectinsEV45Envelope protein UL45 (18 kDa protein)
UL45
P10229
UL45
P89465
gBgBEnvelope glycoprotein B (gB)
UL27
P10211
UL27
P08666
ORF31
P09257
UL55
F5HB53
U39
P28864
U39
P36320
U39
O56280
BALF4
P03188
ORF8
F5HB81
immunoglobulin glycoprotein_RL11gCEnvelope glycoprotein C (gC)
UL44
P10228
UL44
Q89730
ORF14
P09256
immunoglobulin glycoprotein_RL11gCEnvelope glycoprotein C (isoform gCsec)
UL44_gCsec
P10228
immunoglobulin glycoprotein_RL11gDEnvelope glycoprotein D (gD)
US6
Q69091
US6
Q69467
immunoglobulin glycoprotein_RL11gEEnvelope glycoprotein E (gE)
US8
P04488
US8
P89475
ORF68
P09259
immunoglobulin glycoprotein_RL11gGEnvelope glycoprotein G (gG)
US4
P06484
US4
P13290
gHgHEnvelope glycoprotein H (gH)
UL22
P06477
UL22
P89445
ORF37
P09260
UL75
Q6SW67
U48
P68324
U48
P52543
U48
O56284
BXLF2
P03231
ORF22
F5HAK9
immunoglobulin glycoprotein_RL11gIEnvelope glycoprotein I (gI)
US7
P06487
US7
P13291
ORF67
P09258
gJgJEnvelope glycoprotein J (gJ)
US5
P06480
US5
P13293
gKgKEnvelope glycoprotein K (gK) (Syncytial protein)
UL53
P68331
UL53
P22485
ORF5
P09261
gL alphaherpes, gL betaherpesgLEnvelope glycoprotein L (gL)
UL1
P10185
UL1
P28278
ORF60
P09308
UL115
F5HCH8
U82
P52508
U82
P52526
U82
O56297
BKRF2
P03212
ORF47
F5HDB7
gMgMEnvelope glycoprotein M (gM)
UL10
P04288
UL10
P89433
ORF50
P09298
UL100
Q6SW43
U72
Q04630
U72
P52449
U72
Q77Y52
BBRF3
P03215
ORF39
F5HDD0
gNgNEnvelope glycoprotein N (gN)
UL49A
O09800
UL49A
Q86539
ORF9A
Q65ZG0
UL73
F5HHQ0
U46
Q06094
U46
P52547
U46
Q77Y68
BLRF1
P03196
ORF53
F5HFQ0
gOEnvelope glycoprotein O (gO)
UL74
F5HGP1
U47
Q06093
U47
P52549
U47
Q77Y67
GP350Envelope glycoprotein GP350 (Membrane antigen) (MA)
BLLF1
P03200
immunoglobulin glycoprotein_RL11GP350Envelope glycoprotein GP350 (Membrane antigen) (MA) (isoform GP220)
BLLF1_GP220
P03200
GP42Glycoprotein 42 (gp42) [Cleaved into: Soluble gp42]
BZLF2
P03205
gQ1Glycoprotein Q1 (gQ1)
U100
Q69572
U100
Q9QJ11
U100
O56304
DNA helicaseHELIDNA replication helicase
UL5
P10189
UL5
P28277
ORF55
P09303
UL105
F5HEN8
U77
P52356
U77
P52450
U77
O56295
BBLF4
P03214
ORF44
Q2HR89
DNA polymerase and helicase/primaseHEPADNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
UL8
P10192
UL8
P89431
ORF52
P09300
UL102
F5HIG1
U74
P52375
U74
P52451
U74
Q77Y51
BBLF2
P30118
ORF40
Q2HR92
ICP0E3 ubiquitin-protein ligase ICP0 (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)
RL2
P08393
RL2
P28284
ICP22Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)
US1
P04485
US1
P89474
ORF63
P09255
ICP22Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22) (isoform US1.5)
US1_US1.5
P04485
infected cell protein 27ICP27mRNA export factor ICP27 (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)
UL54
P10238
UL54
P28276
ORF4
P09269
UL69
Q6SW73
U42
P52354
U42
P52539
U42
O56283
BSLF2
Q04360
ORF57
Q2HR75
ICP34Neurovirulence factor ICP34.5 (Infected cell protein 34.5)
RL1
P36313
RL1
P28283
uracil-DNA glycosylaseICP4Major viral transcription factor ICP4 (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)
RS1
P08392
RS1
P90493
ORF62
P09310
ICP47ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)
US12
P03170
US12
P14345
IE1Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)
U90_U89
Q69567
mitochondrial ribosomal S10IE2Immediate-early protein 2 (IE2)
U86
Q77Z83
U90_U86
Q9QJ16
IE61E3 ubiquitin-protein ligase IE61 (EC 2.3.2.27) (Immediate-early protein 61) (IE61) (RING-type E3 ubiquitin transferase IE61)
ORF61
P09309
viral interleukin-10IL10HViral interleukin-10 homolog (cmvIL-10) (vIL-10)
UL111A
F5HC71
BCRF1-IL10H
P03180
inner tegument proteinITPInner tegument protein
UL37
P10221
UL37
P89460
ORF21
P09277
UL47
Q6SW85
U30
P52437
U30
Q9QJ38
U30
Q77Y77
BOLF1
P03189
ORF63
F5HEU7
KBZIPE3 SUMO-protein ligase K-bZIP (E3 SUMO-protein transferase K-bZIP)
BZLF1
P03206
K8
Q2HR82
KCPComplement control protein (KCP)
ORF4
Q2HRD4
thymidylate kinaseKITHThymidine kinase
UL23
P0DTH5
UL23
P89446
ORF36
P09250
BXLF1
P03177
ORF21
F5HB62
mitochondrial ribosomal S10LANA1Immediate-early protein LANA1
ORF73
Q9QR71
DUT_3LF1Protein LF1
LF1
Q8AZJ5
DUT_3LF2Protein LF2
LF2
P0C725
immunoglobulin glycoprotein_RL11LMP1Latent membrane protein 1 (LMP-1) (Protein p63)
LMP1
P03230
K1
Q2HRD5
latent membrane protein 2LMP2Latent membrane protein 2 (Terminal protein)
LMP2
P13285
K15
Q9QR69
latent membrane protein 2LMP2Latent membrane protein 2 (Terminal protein) (isoform LMP2B)
LMP2_LMP2B
P13285
large tegument proteinLTPLarge tegument protein deneddylase
UL36
P10220
UL36
P89459
ORF22
P09278
UL48
Q6SW84
U31
P52340
U31
Q9QJ37
U31
O56278
BPLF1
P03186
ORF64
Q2HR64
M1M1 protein (Serpin) (Serpin-1-like protein)
M2Herpesvirus type 68 DNA for tRNA-like sequences and ORF1, ORF2 and ORF3 (M2) (Uncharacterized protein M2)
M3M3 (M3 protein)
M4M4 (Uncharacterized protein M4)
M751 protein (Glycoprotein 150) (M7) (Serine threonine rich glycoprotein)
equilibrative nucleoside transporterMB43Membrane protein UL43
UL43
P10227
UL43
P89464
ORF15
P09273
major capsid proteinMCPMajor capsid protein (MCP)
UL19
P06491
UL19
P89442
ORF40
P09245
UL86
F5HGT1
U57
P17887
U57
Q9QJ26
U57
Q77Y62
BcLF1
P03226
ORF25
Q2HRA7
RING-type E3 ubiquitin transferaseMIR1E3 ubiquitin-protein ligase MIR1 (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)
K3
P90495
RING-type E3 ubiquitin transferaseMIR2E3 ubiquitin-protein ligase MIR2 (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)
K5
P90489
phosphoribosylformylglycinamidine synthaseMTPMajor tegument protein (MTP)
BNRF1
P03179
ORF75
Q9QR70
nuclear egress protein 1NEC1Nuclear egress protein 1
UL31
P10215
UL31
P89454
ORF27
P09283
UL53
F5HFZ4
U37
P28865
U37
Q9WT27
U37
O56279
BFLF2
P0CK47
ORF69
F5H982
nuclear egress protein 2NEC2Nuclear egress protein 2
UL34
P10218
UL34
P89457
ORF24
P09280
UL50
Q6SW81
U34
P52465
U34
Q9QJ35
U34
Q77Y74
BFRF1
P03185
ORF67
F5HA27
mitochondrial ribosomal S10NP03Nuclear phosphoprotein UL3
UL3
P10187
UL3
P28279
ORF58
P09306
DNA replicationNP04Nuclear protein UL4
UL4
P10188
UL4
P28280
ORF56
P09304
origin-binding proteinOBPReplication origin-binding protein (OBP) (OriBP)
UL9
P10193
UL9
P89432
ORF51
P09299
U73
P52378
U73
P52452
U73
O56293
ORF0Membrane protein 0 (Membrane ORF0 protein) (ORF S/L)
ORF0
Q6F6K2
ORF1Structural protein 1 (Structural ORF1 protein)
ORF1
P09266
DUT_3ORF10Protein ORF10
ORF10
Q2HRC9
DUT_3ORF11Protein ORF11
ORF11
Q2HRC8
ORF2Membrane protein 2 (Membrane ORF2 protein)
ORF2
P09267
ORF27 glycoproteinORF27Protein ORF27
BDLF2
P03225
ORF27
F5HDY6
ORF28Protein ORF28
BDLF3
P03224
ORF28
F5HI25
ORF32Phosphoprotein 32 (ORF32 Phosphoprotein)
ORF32
P09285
tegument protein 3ORF35Protein ORF35
BGLF3.5
Q2MG96
ORF35
F5HCD4
ORF45Protein ORF45
BKRF4
P30117
ORF45
F5HDE4
tubulin polyglutamylase ORF48Tegument protein ORF48
BRRF2
P03210
ORF48
Q2HR85
transcriptional activatorORF49Protein ORF49
BRRF1
P03207
ORF49
Q2HR83
replication and transcription activatorORF50Replication and transcription activator (Rta) (Immediate-early protein Rta) (Protein R)
BRLF1
P03209
ORF50
F5HCV3
cGAS inhibitorORF52Tegument protein ORF52 (Kaposi's sarcoma-associated herpesvirus inhibitor of cGAS) (KicGAS)
BLRF2
P03197
ORF52
Q2HR80
ORF57Uncharacterized protein 57 (Uncharacterized ORF57 protein)
ORF57
P09305
equilibrative nucleoside transporterORF58Protein ORF58
BMRF2
P03192
ORF58
F5HAD1
immunoglobulin glycoprotein_RL11OX2VOX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)
U85
Q89738
U85
Q9QJ17
U85
O56299
K14
P0C788
tubulin polyglutamylase P100Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural protein)
U11
Q00701
U11
Q69535
U11
O56271
serine/threonine-protein kinasePKSerine/threonine-protein kinase US3
US3
P04413
US3
P13287
ORF66
P09251
portal proteinPORTLPortal protein
UL6
P10190
UL6
P89429
ORF54
P09302
UL104
F5HBR4
U76
P52453
U76
P52454
U76
O56294
BBRF1
P03213
ORF43
F5HGK9
tubulin polyglutamylase PP150Tegument protein pp150
UL32
Q6SW99
DUT_3PP6565 kDa phosphoprotein (pp65) (65 kDa matrix phosphoprotein) (Phosphoprotein UL83) (Tegument protein UL83)
UL83
Q6SW59
DUT_3PP71Protein pp71
UL82
F5HBC6
tubulin polyglutamylase PP85Phosphoprotein 85 (pp85)
UL25
F5HGJ4
U14
Q69549
U14
Q9QJ49
U14
O56273
DNA primasePRIMDNA primase
UL52
P10236
UL52
P89471
ORF6
P09270
UL70
F5HG51
U43
P52467
U43
P52540
U43
Q77Y71
BSLF1
P03193
ORF56
F5HIN0
ribonucleoside-diphosphate reductase small subunit 1RIR1Ribonucleoside-diphosphate reductase large subunit (R1) (Ribonucleotide reductase large subunit)
UL39
P08543
UL39
P89462
ORF19
P09248
UL45
Q6SW87
U28
P52343
U28
Q9QJ39
U28
Q77Y78
BORF2
P03190
ORF61
Q2HR67
ribonucleoside-diphosphate reductase small subunit 2RIR2Ribonucleoside-diphosphate reductase small subunit (R2) (Ribonucleotide reductase small subunit)
UL40
P10224
UL40
P69521
ORF18
P09247
BaRF1-RIR2
P0CAP6
ORF60
F5HAW0
RNBRNA-binding protein
US11
P04487
US11
P89479
scaffoldSCAFCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein UL26)
UL26
P10210
UL26
P89449
ORF33
P09286
UL80
Q6SW62
U53
P24433
U53
Q9QJ30
U53
O56287
BVRF2
P03234
ORF17
Q2HRB6
SCAFCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein UL26) (isoform pAP)
UL26_pAP
P10210
UL26_pAP
P89449
ORF33_pAP
P09286
UL80_pAP
Q6SW62
BVRF2_pAP
P03234
ORF17_pAP
Q2HRB6
SCAFCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (isoform UL80.3)
UL80_UL80.3
Q6SW62
SCAFCapsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (isoform UL80.4)
UL80_UL80.4
Q6SW62
small capsomere-interacting protein betaherpes, small capsomere-interacting protein alphaherpes, small capsomere-interacting protein gammaherpesSCPSmall capsomere-interacting protein
UL35
P10219
UL35
P89458
ORF23
P09279
UL48A
F5HEN7
U32
Q69560
U32
Q9WT32
U32
Q77Y76
BFRF3
P14348
ORF65
Q2HR63
virion host shutoff protein SHUTVirion host shutoff protein (Vhs)
UL41
P10225
UL41
P68340
ORF17
P09275
tegument protein 1TEG1Tegument protein UL46 (Tegument protein VP11/12)
UL46
P10230
UL46
P89466
ORF12
P09264
tegument protein 3TEG3Tegument protein UL14
UL14
P04291
UL14
P89437
ORF46
P09295
tegument protein 4TEG4Tegument protein UL21
UL21
P10205
UL21
P89444
ORF38
P09289
UL88
F5H9F9
U59
P24438
U59
Q9QJ24
U59
Q77Y61
BTRF1
P30119
ORF23
F5HIM6
tegument protein 5TEG5Tegument protein UL47 (82/81 kDa tegument protein) (VMW82/81) (VP13/14)
UL47
P10231
UL47
P89467
ORF11
P09263
nuclear compartmentsTEG6Tegument protein UL55
UL55
P10239
UL55
P28281
ORF3
P09268
gamma- tegument protein 7 betaherpes, tegument protein 7 alphaherpesTEG7Tegument protein UL51
UL51
P10235
UL51
P89470
ORF7
P09271
UL71
F5HEA3
U44
P52473
U44
P52546
U44
Q77Y70
BSRF1
P0CK49
ORF55
F5H9W9
tripartite terminase subunit 1TRM1Tripartite terminase subunit 1
UL28
P10212
UL28
P89451
ORF30
P09284
UL56
F5HC79
U40
P52384
U40
P52544
U40
O56281
BALF3
P25939
ORF7
Q2HRD2
tripartite terminase subunit 2TRM2Tripartite terminase subunit 2
UL33
P10217
UL33
P89456
ORF25
P09281
UL51
F5HGI9
U35
Q69561
U35
Q9QJ34
U35
Q77Y73
BFRF1A
A0A1P7U110
ORF67A
F5H9W4
tripartite terminase subunit 3TRM3Tripartite terminase subunit 3 (Terminase large subunit)
UL15
P04295
UL15
P89438
ORF42
P09294
UL89
F5HCU8
U60
M9TIH1
U66
Q9QJ23
U60
Q77Y60
BGRF1-BDRF1
P03219
ORF29
F5HGB6
US22_2TRS1Protein TRS1
TRS1
Q6SVX2
triplex capsid protein 1TRX1Triplex capsid protein 1
UL38
P32888
UL38
P89461
ORF20
P09276
UL46
F5HA93
U29
P52348
U29
Q9WT35
U29
O56277
BORF1
P03187
ORF62
F5H8Y5
triplex capsid protein 2TRX2Triplex capsid protein 2
UL18
P10202
UL18
P89441
ORF41
P09291
UL85
F5HIN9
U56
P24436
U56
Q9QJ27
U56
Q77Y63
BDLF1
P25214
ORF26
F5HGN8
thymidylate synthaseTYSYThymidylate synthase (TS) (TSase)
ORF13
P09249
ORF70
P90463
DUT_3U10Protein U10
U10
Q01348
U10
Q9WT54
U10
Q77Y89
viral G-protein coupled receptorU12G-protein coupled receptor homolog U12
U12
P52380
U13Protein U13
U13
Q69548
U13
Q9QJ50
U13
Q77Y88
U15Protein U15
U15
Q69550
U15
Q9QJ48
U15
O56274
U16/U17Protein U16/U17
U17_U16
Q69552
US22_2U17Protein U17
U17
Q69552
U17
Q9QJ47
U17
Q77Y87
immunoglobulin glycoprotein_UL18U18Putative immediate early glycoprotein (Protein U18)
U18
Q69553
U18
Q9WT46
U18
Q77Y86
US22_2U2Protein U2
U2
M9TI14
U2
Q9QJ57
U2
O56269
U20Glycoprotein U20
U20
Q69555
U20
Q9QJ46
U20
Q77Y84
immunoglobulin glycoprotein_UL18U21Glycoprotein U21
U21
Q69556
U21
Q9QJ45
U21
T2C937
U22Glycoprotein U22
U22
Q69557
U22
Q9QJ44
U23Glycoprotein U23
U23
Q69558
U23
Q9QJ43
U23
Q77Y82
U24 proteinU24Protein U24
U24
Q69559
U24
Q9QJ42
U24
Q77Y81
U24A proteinU24AProtein U24A (U24A) (U24A protein)
U24A
M9TND7
U24A
Q9QJ41
U24A
O56275
U47AEnvelope glycoprotein 24 (U47A protein)
U47A
M9TG17
U53.5Capsid scaffold protein (U53.5 protein)
U53.5
A0A0A7RM03
U6Uncharacterized protein U6
U6
Q9QJ53
DNA replicationU79Protein U79/U80
U79_UL80
P52529
U79
P52530
U79
O56296
mitochondrial ribosomal S10U86Immediate-early protein
U86
O56300
mitochondrial ribosomal S10U87IE2
U90_U87U86
Q77Z83
U90Immediate-early protein U90
U90
Q77PU6
U90
O56301
U91Protein U91
U91
Q69569
U91
Q9QJ14
U91
O56302
US22_2U95Uncharacterized protein U95
U95
Q89882
U95
Q9QJ12
U95
O56303
DNA replicationUL112-113Early phosphoprotein p84
UL112-113
Q6SW37
DNA replicationUL112-113Early phosphoprotein isoform p34
UL112-113_p34
Q6SW37
DNA replicationUL112-113Early phosphoprotein isoform p43
UL112-113_p43
Q6SW37
DNA replicationUL112-113Early phosphoprotein isoform p50
UL112-113_p50
Q6SW37
virion morphogenesis and cell fusionUL20Protein UL20
UL20
P10204
UL20
P89443
ORF39
P09290
dispersal of nucleolinUL24Protein UL24
UL24
P10208
UL24
P89447
ORF35
P09288
UL76
Q6SW66
U49
Q06092
U49
P52545
U49
Q77Y66
BXRF1
P03232
ORF20
Q2HRB2
UL3UL3 protein
UL32 packaging proteinUL32Packaging protein UL32
UL32
P10216
UL32
P89455
ORF26
P09282
UL52
Q6SW79
U36
P52463
U36
Q9QJ33
U36
Q77Y72
BFLF1
P03184
ORF68
F5HF47
US22_1UL38Apoptosis inhibitor
UL38
F5HG98
U19
Q69554
U19
Q9WT45
U19
Q77Y85
UL49 viral transcriptional activatorUL49vTA protein UL49
UL49
Q6SW82
U33
P52441
U33
Q9QJ36
U33
Q77Y75
BFRF2
P14347
ORF66
F5HG20
UL56Protein UL56
UL56
P10240
UL56
P28282
UL79 viral transcriptional activatorUL79vTA protein UL79
UL79
Q6SW63
U52
P52469
U52
P52548
U52
O56286
BVLF1
Q2MG95
ORF18
Q2HRB4
UL87 viral transcriptional activatorUL87vTA protein UL87
UL87
Q6SW55
U58
P24437
U58
Q9QJ25
U58
O56290
BcRF1-UL87
P25215
ORF24
F5HFD2
U62 viral transcriptional activatorUL91vTA protein UL91
UL91
F5HFJ8
U62
P24439
U62
Q9QJ22
U62
Q77Y59
ORF30
F5HES7
UL92 viral transcriptional activatorUL92vTA protein UL92
UL92
F5HAS7
U63
P24440
U63
Q9QJ21
U63
Q77Y58
BDLF4
P0CK56
ORF31
Q2HRA1
UL95 viral transcriptional activatorUL95vTA protein UL95
UL95
Q6SW48
U67
P24444
U67
Q9WT06
U67
Q77Y57
BGLF3
P03220
ORF34
Q2HR98
U68 proteinUL96Protein U68
U68
P24445
U68
Q9QJ18
U68
Q77Y56
uracil-DNA glycosylaseUNGUracil-DNA glycosylase (UDG) (UNG)
UL2
P10186
UL2
P28275
ORF59
P09307
UL114
F5HI85
U81
P52345
U81
P52447
U81
Q77Y49
BKRF3
P12888
ORF46
F5HFA1
dihydrofolate reductaseUS02Protein US2
US2
P06485
US2
P13292
US10 capsid associatedUS10Virion protein US10
US10
P06486
US10
P89478
ORF64
P09311
US8.5/US8AProtein US8.5
US8.5
O09802
US8A
P89476
anterograde transport membrane proteinUS9Envelope protein US9 (10 kDa protein)
US9
P06481
US9
P89477
ORF65
P09312
V57
viral chemokineVCCL3Protein vCCL3
K4.1
F5HCJ2
VCYCLviral cyclin homolog (v-cyclin)
ORF72
Q77Q36
VFLIPViral FLICE protein (vFLIP)
ORF71
F5HEZ4
immunoglobulin glycoprotein_UL18VGLIUL37 immediate early glycoprotein
UL37
Q6SW94
immunoglobulin glycoprotein_UL18VGLIUL37 immediate early glycoprotein (isoform pUL37m)
UL37_pUL37m
Q6SW94
VGLIUL37 immediate early glycoprotein (isoform vMIA)
UL37_vMIA
Q6SW94
viral G-protein coupled receptorvGPCRViral G-protein coupled receptor
U12
Q9QJ51
U12
O56272
BILF1
P03208
ORF74
Q98146
US22_2VICAViral inhibitor of caspase-8-induced apoptosis (vICA)
UL36
F5HAY6
mitochondrial ribosomal S10VIE1Immediate early protein IE1 (IE1) (55 kDa immediate-early protein 1) (IE1p72) (IE72)
UL123
F5HCM1
mitochondrial ribosomal S10VIE2Viral transcription factor IE2 (IE2) (Protein UL122)
UL122
Q6SW29
VIL6Viral interleukin-6 homolog (vIL-6)
K2
Q2HRC7
viral interferon regulatory factorVIRF1VIRF-1
K9
F5HF68
viral interferon regulatory factorVIRF2Viral IRF2-like protein (vIRF-2)
K11.1
Q2HR71
viral interferon regulatory factorVIRF3Viral IRF3-like protein (VIRF-3)
K10.2
F5HIC6
viral interferon regulatory factorVIRF4Viral IRF4-like protein (vIRF-4)
K10.1
Q2HR73
viral chemokineVMI2Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) (vMIP-1B)
K4
Q98157
VP16VP16Tegument protein VP16 (Alpha trans-inducing protein) (Alpha-TIF) (ICP25) (Vmw65)
UL48
P06492
UL48
P68336
ORF10
P09265
US22_2, VP22VP22Tegument protein VP22
UL49
P10233
UL49
P89468
ORF9
P09272
UL24
F5H9N4
PCNAvPAPDNA polymerase processivity factor (Polymerase accessory protein) (PAP)
UL42
P10226
UL42
P89463
ORF16
P09274
UL44
F5HC97
U27
P52439
U27
Q9QJ40
U27
Q77Y79
BMRF1
P03191
ORF59
F5HID2
serine/threonine-protein kinaseVPKViral serine/threonine-protein kinase (Virion protein VMW57)
UL13
P04290
UL13
P89436
ORF47
P09296
UL97
Q6SW46
U69
P24446
U69
P52446
U69
Q77Y55
BGLF4
P13288
ORF36
F5HGH5
US22_2VU25Protein U25
U25
P52527
U25
Q9WT39
U25
Q77Y80
VU26Protein U26
U26
P52444
U26
Q9WT38
U26
O56276
US22_2VU3Protein U3
U3
Q01350
U3
Q9QJ56
U3
Q77Y92
US22_0VU4Protein U4
U4
Q01351
U4
Q9QJ55
U4
Q77Y91
viral G-protein coupled receptorVU51G-protein coupled receptor homolog U51
U51
P52382
U51
P52542
U51
Q77Y65
DUT_3VU54Protein U54
U54
P24434
U54
Q9QJ29
U54
O56288
DUT_3VU55Uncharacterized protein U55
U55
P24435
U55
Q9QJ28
US22_4, US22_2VU7Protein U7
U7
Q01353
U7
Q9QJ54
U7
O56270
US22_2VU8Protein U8
U8
Q9QJ52
mitochondrial ribosomal S10VU84Protein U84
U84
P52532
U84
P52533
U84
O56298
VU9Protein U9
U9
Q9WT55
DNA helicaseVU94Protein U94
U94
Q00683
U94
Q9WSZ6
YEC4Uncharacterized protein EC-RF4
EC-RF4
P03235
Protein UL24
UL24
F5H9N4
Protein RL9A
RL9A
F7V996
Uncharacterized protein US33A
US33A
F7V999
Uncharacterized protein UL2
UL2
Q6SWC7
Protein UL148D
UL148D
F5HHL7
Uncharacterized protein US34A
US34A
Q6SVX3
Uncharacterized protein UL74A
UL74A
C1BEG3
Uncharacterized protein UL147A
UL147A
F5H8R0
Protein UL148C
UL148C
F5HDE7
Protein UL41A
UL41A
F5HFG3
UL30A
U3KRG9
Protein UL148B
UL148B
F5HAK6
Protein UL148A
UL148A
F5HE74
Protein RL8A
RL8A
F7V995
Protein RL5A (RL11 family)
RL5A
F5HF23
Uncharacterized protein UL19
UL19
F5HI68
Uncharacterized protein UL15A
UL15A
F5HAE6
Protein UL17
UL17
F5HHT4
Glycoprotein UL22A
UL22A
F5HF90
immunoglobulin glycoprotein_RL11Uncharacterized protein IRL6 (TRL6) (RL11 family)
RL6
Q6SWD3
Uncharacterized protein UL30
UL30
F5HGC2
Uncharacterized protein UL21A
UL21A
F5HH39
Protein UL42
UL42
F5HHZ3
U68 proteinProtein UL96
UL96
F5H8R6
Protein UL131A
UL131A
F5HET4
Protein UL145
UL145
F5HF44
Membrane glycoprotein UL139
UL139
Q6SW14
immunoglobulin glycoprotein_RL11Envelope glycoprotein UL4 (RL11 family)
UL4
Q6SWC6
Uncharacterized protein UL124
UL124
F5HHS3
US1 proteinProtein US1
US1
Q6SW03
Putative viral CXC chemokine 2 (vCXCL2)
UL147
F5HA06
Uncharacterized protein US31
US31
F5HAM4
Protein US34
US34
F5HEF3
Protein UL5 (RL11 family)
UL5
Q6SWC5
Protein UL138
UL138
F5HGQ8
Protein IRL10 (TRL10)
RL10
F5HI32
Membrane glycoprotein UL144 (TNF alpha-like receptor UL144) (UL144 protein)
UL144
F5HAM0
Membrane protein UL121
UL121
F5HD27
Unique short US6 glycoprotein
US6
Q6SW00
US1 proteinProtein US32
US32
F5HD03
Membrane glycoprotein US10
US10
F5HFJ7
immunoglobulin glycoprotein_US8Membrane glycoprotein US3
US3
F5HEU0
Protein UL140
UL140
F5HCK7
immunoglobulin glycoprotein_US8Unique short US2 glycoprotein (Protein HQLF2) (gpUS2)
US2
F5HE05
Membrane protein UL120
UL120
Q6SW31
Envelope glycoprotein UL130
UL130
F5HCP3
immunoglobulin glycoprotein_US8Membrane glycoprotein US11
US11
Q6SVZ5
immunoglobulin glycoprotein_RL11Glycoprotein UL1 (RL11 family)
UL1
Q6SWC8
Protein UL40
UL40
Q6SW92
US22_1Tegument protein UL26
UL26
F5HGG3
US22_1Tegument protein UL26 (isoform UL26.21)
UL26_UL26.21
F5HGG3
immunoglobulin glycoprotein_RL11CEACAM1-like protein UL7 (RL11 family)
UL7
Q6SWC3
Membrane glycoprotein US7
US7
F5HDD3
immunoglobulin glycoprotein_US8Membrane glycoprotein US8
US8
F5HB52
Protein UL16
UL16
F5HG68
immunoglobulin glycoprotein_RL11Membrane glycoprotein UL9 (RL11 family)
UL9
F5H9T4
immunoglobulin glycoprotein_RL11Membrane glycoprotein RL11 (RL11 family)
RL11
Q6SWD1
baxTransmembrane protein US19
US19
F5HAR3
Protein UL136
UL136
F5HF35
Membrane protein US21
US21
F5HHT6
immunoglobulin glycoprotein_US8Membrane glycoprotein US9
US9
F5HC33
baxMembrane protein US20
US20
F5HGH8
immunoglobulin glycoprotein_RL11Uncharacterized protein UL10 (RL11 family)
UL10
Q6SWC0
Protein UL133
UL133
Q6SW10
baxMembrane protein US13
US13
F5H9I4
US15 membrane proteinMembrane protein US15
US15
F5HFH0
Envelope glycoprotein UL132
UL132
F5HGU6
Uncharacterized protein UL150A
UL150A
F7V998
immunoglobulin glycoprotein_RL11Protein UL11 (RL11 family)
UL11
Q6SWB9
baxTransmembrane protein US18
US18
F5HE69
immunoglobulin glycoprotein_RL11Uncharacterized protein UL6 (RL11 family)
UL6
Q6SWC4
baxUncharacterized protein US12
US12
F5HE44
US22_2Tegument protein UL23
UL23
F5HDM3
baxProtein US17
US17
F5H9N9
immunoglobulin glycoprotein_RL11Membrane protein RL13 (RL11 family)
RL13
Q6SWC9
immunoglobulin glycoprotein_UL18Membrane glycoprotein UL142
UL142
F5HHH2
Protein UL135
UL135
F5HAQ7
US15 membrane proteinProtein US16
US16
Q6SVZ0
baxMembrane protein US14
US14
F5HD92
Uncharacterized protein HKLF1 (IRL1) (TRL1)
RL1
Q6SWD5
Uncharacterized protein UL116
UL116
Q6SW34
immunoglobulin glycoprotein_RL11Membrane protein UL148
UL148
F5H8Q3
immunoglobulin glycoprotein_RL11Membrane glycoprotein UL8 (RL11 family)
UL8
A0A1P7U1I1
immunoglobulin glycoprotein_RL11Uncharacterized protein UL14
UL14
Q6SWB7
Membrane protein UL20
UL20
F5H9Z4
immunoglobulin glycoprotein_RL11Protein UL141
UL141
Q6RJQ3
immunoglobulin glycoprotein_RL11Viral Fc-gamma receptor-like protein UL119 (gp68)
UL119-118
F5HC14
Uncharacterized protein US30
US30
F5HB41
viral G-protein coupled receptorEnvelope protein US28 (vGPCR family)
US28
F5HF62
viral G-protein coupled receptorEnvelope glycoprotein US27 (vGPCR family)
US27
F5HDK1
immunoglobulin glycoprotein_UL18Membrane glycoprotein UL18
UL18
F5HFB4
Transcriptional regulator UL34
UL34
F5HC16
viral G-protein coupled receptorG-protein coupled receptor homolog UL33 (vGPCR family)
UL33
Q6SW98
immunoglobulin glycoprotein_RL11Uncharacterized protein RL12 (RL11 family)
RL12
Q6SWD0
US22_2Tegument protein UL43
UL43
Q6SW89
mitochondrial ribosomal S10Protein UL117 (pUL117)
UL117
F5HFA5
mitochondrial ribosomal S10Protein UL117 (pUL117) (isoform UL117.5)
UL117_UL117.5
F5HFA5
viral G-protein coupled receptorProtein UL78 (vGPCR family)
UL78
F5HET1
Uncharacterized protein US29
US29
F5HG95
Uncharacterized protein UL13
UL13
Q6SWB8
US22_2Tegument protein US24
US24
F5H8S6
US22_2Tegument protein US22
US22
F5HDC7
DUT_3Protein UL84
UL84
F5HB40
US22_2Protein US23
US23
F5HAZ3
DUT_1Protein UL31
UL31
Q6SWA0
US22_2Protein US26
US26
F5H991
US22_1Protein UL27
UL27
Q6SWA4
Uncharacterized protein UL150
UL150
Q6SW05
tubulin polyglutamylase Tegument protein UL35
UL35
F5HE12
Tegument protein UL35
UL35_UL35A
F5HE12
Early phosphoprotein isoform p34
UL112-113_p34
Q6SW37
Early phosphoprotein isoform p50
UL112-113_p50
Q6SW37
US22_4Protein UL29/28
UL29
Q6SWA3
US22_2Protein IRS1
IRS1
Q6SW04
Protein IRS1 (isoform IRS1-263)
IRS1_IRS1-263
Q6SW04
Envelope protein UL128
UL128
V9LLX6
U55A
O56289
U53.5
O92828
U47A
Q2V073
DUT_3
U55B
Q77Y64
Protein BNLF2a
BNLF2a
P0C739
Uncharacterized protein BNLF2b
BNLF2b
Q8AZJ3
Uncharacterized protein RPMS1
RPMS1
Q9Q2P0
Uncharacterized protein BLLF2
BLLF2
P03199
Apoptosis regulator BALF1
BALF1
P0CK58
immunoglobulin glycoprotein_RL11Secreted protein BARF1 (33 kDa early protein) (p33)
BARF1
P03228
immunoglobulin glycoprotein_RL11Glycoprotein BILF2
BILF2
P03218
Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)
EBNA2
P12978
Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) (Epstein-Barr nuclear antigen 5) (EBNA-5) (EBV nuclear antigen 5)
EBNALP
Q8AZK7
mitochondrial ribosomal S10Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)
EBNA1
P03211
Uncharacterized protein BHLF1
BHLF1
P03181
Uncharacterized protein LF3
LF3
P0C727
Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) (EBNA-3B) (EBV nuclear antigen 3B)
EBNA3B
P03203
Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A)
EBNA3A
P12977
Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C)
EBNA3C
P03204
BARF0
Q8AZJ4
A0A1P7U1U3
A0A1P7U1U3
Protein K12
K12
Q77Q38
viral chemokineProtein K6
K6
F5HET8
Protein K7
K7
F5HDA4
Protein K4.2
K4.2
F5HF36
Protein K8.1
K8.1
F5HB98
75a (Tegument protein/FGARAT) (ORF75 family)
75b (Tegument protein/FGARAT) (ORF75 family)
75c (Tegument protein/FGARATc) (ORF75 family)

This is a project in cooperation with the Topf lab at CSSB.

The predictions are visualised using 3Dmol.js:

Predictions were run with ColaFold by the Steinegger lab:

As well as Deepmind for Alphafold2:

Protein homologs were checked with an all-against-all structural comparison performed using DALI:


Herpesfolds is distributed under the MIT licence:

Copyright 2024, Prof. Dr. Jens Bosse

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the “Software”), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED “AS IS”, WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.