Viruses assemble in a complex order of consecutive morphogenesis events. Our research aims to illuminate the spatiotemporal regulation of these morphogenesis events at the single-particle level. We use three-dimensional live-cell microscopy to quantify the kinetics and dynamics of viral macromolecular complexes in living cells at the single-particle level and create computational pipelines to analyze large image datasets. Correlative electron microscopy complements our measurements with ultrastructural data on cellular organization. Proteome-wide structural predictions of viral proteins and their interactions now enable structural systems biology of virus morphogenesis.
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